Cefpirome is another broad spectrum cephalosporin for intravenous use. Its antimicrobial activity is similar to that of cefotaxime.
The reconstituted drug can be injected over 3-5 minutes or given as a 20-30 minute infusion. Clearance is mainly renal so a lower dose is given if creatinine clearance is reduced. The half life is 2 hours, but cefpirome can usually be given twice a day.
Cefpirome is stable to beta lactamases and has activity against staphylococci, streptococci, and Gramnegative organisms including Escherichia coli, Haemophilus influenzae and Moraxella catarrhalis . The drug is active against Pseudomonas aeruginosa, but may be less active than ceftazidime.